NMS PAIN RELIEF SUPPLEMENT

NMS is a fast acting all-natural supplement that is powerful and effective in reducing or eliminating the pain and inflammation associated with the following conditions:

• Back Pain
• Neck Pain
• Chronic Joint Pain
• Osteoarthritis
• Leg Pain
• Muscle Strain
• Arthritis
• Muscle pain and inflammation from exercise or running
• Everyday Bumps and Bruises

Published scientific studies of each of the nutrients in the NMS formula have demonstrated an ability to reduce inflammation and pain. Other studies have shown that some of the ingredients when tested together produced a synergistic effect resulting in greater relief. None of the studies has indicated a possible conflict or interaction with prescription medications. If you have any questions involving the use of this product and any of your medications, consult your doctor before taking them together.

Formula for NMS Neuromuscular Support™

There are a great number of scientific studies and books that have been published on each of the ingredients contained in the formula and this paper will provide an insight into some of those that demonstrated or indicated  ability to effect pain and inflammation in some manner.

Thiamine is one of the B vitamins, a group of water‑soluble vitamins that participate in many of the chemical reactions in the body. Water‑soluble vitamins dissolve in water. The body cannot store them. Leftover amounts of the vitamin leave the body through the urine. That means you need a continuous supply of such vitamins in your diet.
Thiamine (vitamin B1) helps the body cells convert carbohydrates into energy. It is also essential for the functioning of the heart, muscles, and nervous system.
A 1998 German study demonstrated that high doses of B1, B6, and B12 administered separately or in combination can alleviate acute pain. Therapeutic effects were observed in neuropathic pain and pain of musculoskeletal origin.[1]  An 1996 Indian scientific study of 556 girls aged 12-21 yr. having moderate to very severe spasmodic dysmenorrhea were given an oral daily dose of 100 mg of Vitamin B1 for 90 days. 87 percent were completely cured, 8 percent relieved (pain almost nil to reduced) and 5 percent showed no effect whatsoever.[2]

Vitamin B6 is a water‑soluble vitamin. It performs a wide variety of functions in your body and is essential for your good health. For example, vitamin B6 is needed for more than 100 enzymes involved in protein metabolism. It is also essential for red blood cell metabolism. The nervous and immune systems need vitamin B6 to function efficiently, [5-8] and it is also needed for the conversion of tryptophan (an amino acid) to niacin (a vitamin) [3,9].

DLPA Phenylalanine. There are three different types of this amino acid. They are the L form, the D form and the D-L form. They show differing reactions on the body. L-phenylalanine: is associated with nervous states and has anti-depressant properties. D-phenylalanine: enhances the effects of painkillers. It has also been used for Parkinson's Disease and has anti-depressant properties. The memory of some patients may be enhanced with this form of amino acid.
DL-phenylalanine: may be used as a painkiller, especially for chronic, long-term pain e.g., arthritis. It may also be beneficial to people suffering from skin conditions e.g., vitiligo.  DLPA works by slowing down the enzymes that degrade the biological Endorphins (neurohormones) produced in the brain.  Edorphins are our “natural” internal painkillers and mood elevators. DLPA increases endorphin concentrations and provides additional comfort against chronic aches and pains, as well as helping to relieve depression and premenstrual syndrome (PMS) conditions.[10]

CURCUMIN.  Inflammation is now recognized as an overwhelming burden to the healthcare status of our population and the underlying basis of a significant number of diseases.  Curcumin (a component or turmeric) has long been used as a spice and food-coloring agent.  In experimental animals, curcumin has shown anti-diabetic, anti-inflammatory, cytotoxic and anti-oxidant properties as well as a lipid lowering effect.[11]    It possesses divers anti-inflammatory and anti-cancer properties following oral or topical administration.[12] Curcumin was found to be pharmacologically safe in human clinical trials with doses up to 10/grams/day[13] A phase 1 human trial with 25 subjects using up to 8000 mg of Curcumin per day for 3 months found no toxicity from Curcumin.[14]

BOSWELLIA.  Gum resin extracts of Boswellia species have been traditionally applied in folk medicine for centuries to treat various chronic inflammatory diseases, and experimental data from animal models and studies with human subjects confirmed the potential of Boswellia species extracts for the treatment of not only inflammation but also cancer.[15] Osteoarthritis is a common, chronic, progressive, skeletal, degenerative disorder, which commonly affects the knee joint.  Boswellia serrata extract was demonstrated to be effective in reducing knee pain, decreased swelling in the knee joint, increased knee flexion and increased walking distance.[16] In clinical trials promising results were observed in patients with rheumatoid arthritis, chronic colitis, ulcerative colitis, Chrohn's disease, bronchial asthma and peritumoral brains edemas.[17]

BROMELAIN.  Bromelain is not a single substance, but rather a collection of enzymes and other compounds.  It is a mixture of sulfur-containing protein-digesting enzymes—called proteolytic enzymes or proteases. Bromelain can be used in a vast array of medical conditions.  It was first introduced in this area in 1957, and works by blocking some proinflammatory metabolites that accelerate and worsen the inflammatory process.  It is an anti-inflammatory agent, and so can be used for sports injury, trauma, arthritis, and other kinds of swelling.[18]  Bromelain may be of interest to plastic surgeons because of its apparent ability to reduce pain, edema, inflammation, and platelet aggregation, as well as its ability to potentiate antibiotics.[19]

QUERCETIN.  Quercetin belongs to a group of plant pigments called flavonoids.  Flavonoids, such as quercetin provide many health-promoting benefits.  Quercetin can act as an antihistamine (help in reducing allergy symptoms) and help reduce inflammation associated with various forms of arthritis. Quercetin also works as an antioxidant by scavenging damaging particles in the body known as free radicals.[20]

• Leklem JE. Vitamin B6. In: Shils ME, Olson JA, Shike M, Ross AC, ed. Modern Nutrition in Health and Disease. 9th ed. Baltimore: Williams and Wilkins, 1999: 413-421.
• Jurna I, Schmerz. 1998 Apr20;12(2):136-141.  Analgesic and analgesia-potentiating action of B vitamins [Article in German]
• Gokhale, LB. Indian J Med Res. 1996 Apr;103:22731  Curative treatment of primary (spasmodic) dysmenorrhea.
• Leklem JE. Vitamin B6. In: Shils ME, Olson JA, Shike M, Ross AC, ed. Modern Nutrition in Health and Disease. 9th ed. Baltimore: Williams and Wilkins, 1999: 413-421.
• Gerster H. The importance of vitamin B6 for development of the infant. Human medical and animal experiment studies. Z Ernahrungswiss 1996; 35:309-17.
• Bender DA. Novel functions of vitamin B6. Proc Nutr Soc 1994; 53:625-30.
• Chandra R and Sudhakaran L. Regulation of immune responses by Vitamin B6. NY Acad Sci 1990; 585:404-423.
• Trakatellis A, Dimitriadou A, Trakatelli M. Pyridoxine deficiency: New approaches in immunosuppression and chemotherapy. Postgrad Med J 1997; 73:617-22.
• Shibata K, Mushiage M, Kondo T, Hayakawa T, Tsuge H. Effects of vitamin B6 deficiency on the conversion ratio of tryptophan to niacin. Biosci Biotechnol Biochem 1995; 59:2060-3.
• DLPA To End Chronic Pain and Depression by Arnold Fox, M.D. and Barry Fox. Published in 1985 by Long Shadow Books (New York, NY).
• Kandarkar SV, Sawani SS, Ingle, AD, et al. Subchronic oral hepatotoxicity of turmeric in mice—histopathological and ultra structural studies.  Indian J Exp Biol 1998 Jul;36(7):675-670
• Babu PS, et al. Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozocin induced diabetic rats. Mol Cell Biochem. 1997;166:169-175
• Aggarwal BB, Kumar A, Bharti AC. “Anticancer potential of Curcumin: preclinical and clinical studies.” Anticancer Res. 2003 Jan-Feb;23(1A):363-98.
• Chainani-Wu N. “Safety and anti-inflammatory activity of Curcumin: a component of turmeric (Curcuma longa).” J Altern Complement Med. 2003 Feb 9(1):161-8.
• Curr Med Chem. 2006;13(28):3359-69.  Boswellic acids: biological actions and molecular targets.
• Kimmatkar N, Thawani V, et al. Phytomedicine, 2003 Jan;10(1):3-7.  Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee—a randomized double blind placebo controlled trial.
• Wien Med Wochenschr. 2002;152(15-16):373-8. Boswellic acids (components of frankincense) as the active principle in treatment of chronic inflammatory diseases. [Article in German]
• Kelly G.S. N.D. Bromelain: A Literature Review and Discussion of it Therapeutic Applications (Alt Med Rev 1996;1(4):243-257)
• Orsini R.A.  Plast Reconstr Surg 2006 Dec;118(7):1640-4. Bromelain
• University of Maryland Medical Center, Center of integrative medicine. http://www/altmed/ConSupplements/Quercetines.htm